Ok, since it's not 3 people mentioning it What are the downsides you have seen to using the standard serial connection instead of USB on units that offer it? In the past I've had programs (Map'n'go I think) require a restart to see the GPS again after it was removed/turned off while the software was running. I've had no problems with the USB connection on my Garmin and desktop PC, which is why I'm leaning that way. And I love this cartoon linked to from the site Rick listed. 
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